Blood Acth and Plasma Corticosteroids in Man during Exposure to Simulated Altitude and High Ambient Temperature

摘要

Hypoxia (equivalent to that at 14,000 feet altitude) acting alone or in combination with high ambient temperature (50 + 1° C, humidity less than 20 percent), and high ambient tem¬perature acting alone induced no significant changes in the peripheral blood ACTH, plasma 17-hydroxycorticosterone, and corticosterone-like steroids of healthy male subjects exposed for periods of 15 to 45 minutes. In one experi¬ment, 3 of 5 subjects who experienced hypoxia in a chamber heated to this same level exhibited an increase in the concentration of peripheral plasma 17-hydroxycorticosterone concentration at the end of 3 hours. In a second experiment, 5 of 8 subjects exhibited an increase at the end of 2 hours of exposure