Studies on Thyroid Function, P. B. I. And Prothrombin Time of Monkeys Treated with Repeated Doses of Nsc 45388, Imidazole-4(Or 5)- Carboxamide, 5(Or 4)3,3-Dimethy1-1-Triazeno)

摘要

Compound NSC 45388, Imidazole-4(or 5)-carboxamide, 5(or 4)-3,3-dimethy1-1-triazeno)when administered to monkeys at a dose of 60 mg/kg/day (780 mg/M sq/day) was lethal to the animals after five and ten doses. These studies were initiated primarily to determine whether or not drug administration would produce alterations in P.B.I. and prothrombin time of the animals. In one of two animals (No. 101F) there was a terminal decrease in P.B.I. associated with a hypothermia, and in the other animal (No. 102M) there was a questionable decrease in P.B.I. terminally also associated with hypothermia. These changes did not occur during drug treatment but only occurred at the time the animals were moribund or in poor condition. On microscopic examination no abnormal findings were noted in the thyroids. In contrast during drug treatment leucopenia, anemia and thrombocytopenia were noted. In neither animal was there any change in the prothrombin time. Since the alterations in P.B.I. were associated with an agonal condition of the animals and there were no definitive histological changes in the thyroids the evidence would indicate that the alterations in P.B.I. were not unequivocally drug related. (Author)