Epidemiology and Development of Detection Systems for Cytomegalovirus as Transmitted by Blood Transfusion. CMV Transmission by Blood Transfusion.

摘要

The study is designed to ascertain the relative importance of intravenous transmission of cytomegalovirus (CMV) versus activation of latent infection,determine the incidence and severity of symptoms and evaluate parameters which might serve as screening methods for identification of patients with cytomegaloviremia. Infants undergoing exchange transfusion,patients receiving kidney transplants,and pregnant teenagers with CMV infection have been studied. Six of the 24infants (25%) followed for three months post exchange transfusion have remained well but have developed CMV infection. Forty-one of 59renal transplant recipients (69%) followed for three months have developed CMV infection as evidenced by either culture positivity or a four-fold or greater rise in antibody. There has been little difference in the clinical course of the CMV infected patients as compared to those with no evidence of infection. Twenty-two of 224pregnant teenagers (10%) had CMV infections on initial screening of urine,saliva,and buffy coat. All were asymptomatic.