Guidance for Waiving or Bridging of Mammalian Acute Toxicity Tests for Pesticides and Pesticide Products (Acute Oral, Acute Dermal, Acute Inhalation, Primary Eye, Primary Dermal, and Dermal Sensitization).

摘要

The Office of Pesticide Programs (OPP), US EPA, has previously issued memoranda and other written documents describing criteria that can be cited by registrants to bridge data for or support a waiver of the requirement for mammalian acute toxicity data for pesticide technical active ingredients and pesticide end use formulations. These documents and explanations of criteria to support waiver and bridging requests have appeared in several Agency publications over the years, which can lead to confusion for registrants seeking accurate and updated guidance. This paper integrates information from various Agency documents and other memoranda, as relevant, into one document that can be used as a single reference source for acute toxicity waiver guidance as well as criteria for bridging of acute toxicity data. The purpose of this document is to consolidate information from these sources and provide a single source for consultation on the use of waiver and bridging criteria for acute toxicity testing.