Intravenous Elimination and Percutaneous Absorption of Topically Applied Melphalan-14C (NSC-8806) in Yorkshire White Pigs.

摘要

The distribution and elimination of intravenously administered Melphalan-14C (NSC-8806) was studied in female, weanling Yorkshire white pigs. A three compartment pharmacokinetic model is indicated with a very slow elimination phase (half life = 214hours). Assay of tissue samples indicate bone and fat may be acting as depots for the drug. After 8days an average of 70% was eliminated via the urine. Percutaneous studies showed an average of 4.02% of the applied dose was absorbed after 14days. Significant levels of radioactivity were also detected in skin surrounding the site of application.