Study of the Application of Acrylic Filming Agents for Coating of Solid Pharmaceutical Forms

摘要

The study investigates new acrylic filming agents, comparing them to closely related acrylic filming agents already on the market. It also seeks to demonstrate the possibility of using such acrylic derivatives in the new technique of coating by using a bed of fluidized air, supplanting the traditional coating by turbine. The acrylic filming agents were stomach-soluble and intestine soluble. The influence of four plasticizers on five different concentrations were studied. Endragit E/100 and Orcryl 8/76 on the one hand, and Endragit L/100 and Orcryl 2/72 on the other, were found to have similar reactions, with no effect on the action of the coating solutions. No significant difference in time for dissolution of the comparable coatings was found. Orcryl R filming agents were found to be best adapted to use for coating when using a bed of fluidized air rather than turbines, since they provided a good quality film.