PHS (Public Health Service) Study of the Reye Syndrome: An Initial Evaluation

摘要

Since its characterization 20 years ago (Reye, 1963), the Reye syndrome (RS) has become recognized as an acute, rare, but serious disorder of childhood in which vomiting and coma develop three to four days after a prodromal viral illness. A number of studies have implicated salicylates as a causal factor in the Reye syndrome. The review by the Institute of Medicine Committee on the Reye syndrome and medications was conducted solely with reference to the scientific issues raised in the 'Proposal for a Study Concerning the Possible Association Between Reye Syndrome and Salicylates' prepared by the PHS Reye Syndrome Task Force. In brief, the committee concludes that the task force is not sufficiently prepared to begin an investigation by November 1983 as proposed. The reasons for the conclusion are summarized in the report.