Teratologic Evaluation of Chlorpromazine Hydrochloride (CAS Number 69-09-0) Administered to CD-1 Mice on Gestational Days 6 through 15

摘要

Chlorpromazine HCI (CPZ), a widely used major tranquilizer (antipsychotic), was evaluated for toxic and teratogenic effects in timed-pregnant CD-1 mice which were matched for body weight across treatment groups on gestational day (gd) 0. CPZ (0, 2.5, 5, 15, or 30 mg/kg/day, po) in distilled water was administered in a volume of 0.01 ml per gram of body weight on gd 6 through 15. Females were weighed and observed daily during treatment and at 1 and 4 hours post-dosing for clinical signs of toxicity. At sacrifice on gd 17, a total of 24-29 dams (i.e., confirmed-pregnant females) per treatment group were evaluated. The gravid uterus of each dam was weighed and the number of implantation sites, and live, dead or resorbed fetuses were recorded. All live fetuses were weighed and examined for external, visceral and skeletal malformations.