Clinical Trial of a Combined MFP-NaF Dentifrice Formulated at Different Concentrations

摘要

The two- and three-year caries increments of fifth to seventh grade students (mean age 11.7 years) residing in two fluoride-deficient communities (F < 0.1 ppm) on Long Island, New York, were compared relative to their use of different fluoride dentifrices. Group I used a conventional 0.76 percent Na2PO3F dentifrice (1000 ppm F) and served as the positive control. Group II used a mixed fluoride dentifrice containing equimolar amounts of NaF and Na2PO3F which provided a total fluoride concentration of 1000 ppm. Group III also used a mixed fluoride dentifrice containing equimolar amounts of NaF and Na2PO3F with a total fluoride concentration of 2500 ppm. Brushing was performed unsupervised at home for up to 35 months. There were no statistically significant differences (F-test) in the two- and three-year caries increments between the dentifrice groups for DMFT, DMFS, DMFS of specific tooth surface types, and DMFT and DMFS of teeth that erupted during the study. Mitigating factors which may have influenced the results were the low proximal caries increments and the degree of compliance.