Approach to Identifying Specialized Batteries of Bioassays for Specific Classes of Chemicals: Class Analysis Using Mutagenicity and Carcinogenicity Relationships and Phylogenetic Concordance and Discordance Patterns. 1. Composition and Analysis of the Overall Data Base. A Report of Phase 2 of the U.S. Environmental Protection Agency Gene-Tox Program

摘要

The major utility and/or benefit of this compilation will be derived from a chemical class by chemical class comparative analysis of individual assay performance. The data base will serve as a resource for hazard evaluation of chemicals through structural correlations and biological end points and associated end points such as carcinogenicity. An example analysis is presented using chemical Class 5 (alkyl sulfates sulfoxides, sulfones, sulfonates, organic sulfur compounds not otherwise classified) and includes the four components. (Copyright (c) Elsevier Science Publishers B.V. (Biomedical Division).)