Detection of Hypothyroidism in Infants with Down Syndrome

摘要

Adolescents and adults with Down Syndrome have an increased prevalence of thyroid dysfunction, ranging from 13-54% in different studies. The thyroid dysfunction has been reported to be positively correlated with thyroid antibody levels. The study compared the thyroid function of Down syndrome newborns with matched controls to determine the incidence of hypothyroidism of Down syndrome infants in the first year of life when treatment is most beneficial and to carry out a longitudinal study to determine whether the onset of hypothyroidism coincided with the elevation of thyroid antibodies in Down syndrome children.