Preparation for Human Study of Pesticide Applicators: Sister Chromatid Exchanges and Chromosome Abberrations in Cultured Human Lymphocytes Exposed to Selected Fumigants

摘要

In the project, it was wished to establish beforehand the possible genotoxic effects of selected pesticides, including several fumigants and one organophosphate (OP) in vitro in anticipation of a human study of genotoxicity of exposed fumigant/pesticide applicators. The process was essential to the study since commonly used fumigants have not been extensively studied for genotoxicity. The objective was to examine whether or not in vitro cytogenetic evaluation would be predictive of an in vivo effect of the fumigants under conditions of normal use. Since human exposure may be at a relatively low level and for short duration (an hour or less), it was attempted to use in vitro conditions to mimic acute short term in vivo exposure. (Copyright (c) 1990 Wiley-Liss, Inc.)