Chamber Tests with Human Subjects XX. Hypersensitivity to H as Demonstrated by Patch Tests Before and After Chamber Exposure to H Vapor.

摘要

A series of sensitivity tests on men before and after exposure to H vapor is described in this report. Doses of 1, 1/2, 1/4, and 1/8 micrograms of H in mineral oil, worn as closed patches on the forearm for four hours, represented a satisfactory subvesicant level for determining altered sensitivity. The intensity of reaction to patch tests by previously unexposed men showed a marked variation directly proportional to the outside effective temperature at the time the patches were worn. In addition to erythema, edema and/or folliculitis were observed in only 2 of 230 men tests prior to exposure to H vapor. After exposure, 26% of 169 men manifested edema and/or folliculitis to patch tests. These men were arbitrarily considered 'sensitized'/ This sensitized group also showed a more intense erythema for each does and a lower threshold dose for perceptible erythema than the non-sensitized group. Cases of abnormal generalized skin reaction following exposure to H vapor in the man- chamber are discussed. Eight kodachrome prints, illustrating pertinent features, are included.