Screening of Kenyan medicinal plants for antimalarial effects on Plasmodium falciparum in vitror. Final report for the period 15 December 1993 - 31 December 1994

摘要

The antimalarial activities of extracts of Albizia gummifera and Aspilia mossambicensis against culture adapted isolates of Plasmodium falciparum were evaluated using an in citro (sup 3)H-hypoxanthine uptake technique. Chloroquine was used as a standard antimalarial drug for comparison with the plant extracts. The plant extracts showed various levels of activities (expressed as 50% inhibitory concentration (IC(sub 50)s) in ug/ml of test culture) against P. falciparum in vitro, with Al gummifera showing the highest activity (eman IC(sub 50) of 5.98 (+-) 2.9 SD, n=6), followed by A. mossambicensis (mean IC(sub 50) 73.36 (+-) 59.3 SD, n=18). The mean antimalarial activity of chloroquine (in ug/ml) was 0.037 ((+-) 0.04 SD, n=10), far higher than that of the plant extracts. (author). 5 refs, 2 tabs. (Atomindex citation 28:027904)