Chiral Amide Directed Assembly of a Diastereo- and Enantiopure Su-pramolecular Host and its Application to Enantioselective Catalysis of Neutral Substrates.

摘要

The synthesis of a novel supramolecular tetrahedral assembly of KnGa-iLa stoichiometry is reported. The newly designed chiral ligand exhibits high diastereoselective control during cluster formation, leading exclusively to a single diastereomer of the desired host. This new assembly also exhibits high stability toward oxidation or a low pH environment, and is a more robust and efficient catalyst for asymmetric organic transformations of neutral substrates.