Evaluation of Tri(2-ethylhexyl)trimellitate in the Cho/hgprt Foward Mutation Assay (final Report) with Cover dated 092485.

摘要

The ability of tris(2-ethylhexyl) trimellitate to induce mutations at the HGPRT locus in Chinese hamster ovary (CHO) cells in vitro was evaluated in the presence and absence of induced rat liver S9 metabolic activation. Based on preliminary toxicity tests, non-activated cultures treated with 5, 10, 20, 50, 100, or 200 nl/ml were cloned, producing a cloning efficiency ranging from 91.8 to 148.9% relative to solvent controls (aqueous ethanol). Assays at the same concentrations with metabolic activation produced a cloning efficiency ranging from 73.3 to 162.3%. The test material did not induce dose-related increases in the mutationfrequency relative to solvent control.