METABOLISM IN THE RAT STUDIED BY ISOTOPE TECHNIQUES. II. THE BODY BURDEN OF MERCURY AFTER SINGLE AND MULTIPLE INJECTIONS

摘要

The whole body counts indicate three phases in the clearance of mercury from rats, a rapid phase involving 35% of the dose, lasting for a few days; a slower phase involving 50% of the dose with a half-time of 30 days, and finally a slow phase involving 15% of the dose with a half-time of approximately 100 days. After the first few days, most of the mercury is located in the kidney so that the two slow phases of excretion represent mainly the clearances from the kidney. The patterns were the same for mercury whether, administered by the intravenous or the intramuscular route.