HUMAN URINARY N-ACETYL-&-GLUCOSAMINIDASE:BIOCHEMICAL CHARACTERIZATION AND USE IN RENAL TOXICOLOGY

摘要

The primary emphasis of this research was to characterize the biochemical properties and excretion of an acid hydrolase from human kidney and urine for purposes of its use in the detection and study of certain pathologic or possibly physiologic states of the kidney;and second to develop the actual application of human acid hydrolase excretion to detection of sub-pathogenic drug pephrotoxicity and alteration of such by drug structural modifi¬cation. Although the emphasis was on these applications, con¬siderable basic information has accrued.