Indocyanine Green Labeled with exp 123 I for Dynamic Studies of the Hepato-Biliary System

摘要

This report summarizes the results to develop an iodine-123 labeled agent for dynamic studies of the hepato-biliary system. Iodine-123 is an ideal nuclide for radiopharmaceuticals, because of its short half-life (T/sub exp 1 / sub 2 / = 13.3 hr); its decay with a high abundance (83%) of 159 keV photons; and the reduced patient radiation exposure (a factor of 100 less than iodine-131). Indocyanine green, a tricarbanocyanine dye, was introduced by Heseltine and co-workers in 1956, has several characteristics which suggested that iodine-123 labeled ICG might be potentially useful for hepatic functional evaluation. The plasma clearance and biliary excretion kinetics of exp 123 I-ICG (in dogs) will be compared to exp 131 I-rose bengal and bromosulphalein labeled with iodine-125. (ERA citation 01:014595)