Genetically Programmed Abnormalities of Cell Interactions

摘要

Taken as a whole, the effects of the T/t locus mutations on the functional, morphological, and serological properties of embryonic and spermatogenic cells justify interpretations that the cell membrane is involved. At present no judgment can be made as to whether the abnormalities seen are primary effects of the mutant genes, or secondary to some other, as yet unknown defects. Nevertheless, these mutants offer the opportunity to characterize and identify membrane molecules lying at the cell surface and mediating intercellular interactions, but also molecules at the inner face of the membrane that may be important in transducing or implementing information coming from the outside. (ERA citation 03:009047)