Possible Use of exp 60 Co Irradiation Attenuated Vaccine for the Control of Human Leishmaniasis in Ethiopia. Part of a Coordinated Programme on the Use of Nuclear Techniques in the Preparation of Vaccines Against Parasitic Diseases. Final Report for the Period 15 March 1973 - 28 February 1977

摘要

Radiation effects and the evaluation of radiation-attenuated organisms as vaccines was studied with Leishmania enriettii infections in guinea pigs. The use of heat-killed or live but radiation-attenuated promastigotes with or without the concurrent use of BCG as adjuvant failed to elicit protection to challenge with normal virulent organisms. The effects of varying several factors such as irradiation dose, internal from vaccination to challenge, and the use of irradiated macrophages infected with leishmanial organisms failed to elicit protective immunity. (Atomindex citation 10:448720)