Value of the Indirect Immunoradiometric Assay of Serum alpha - Fetoprotein in Detecting Liver Regeneration and Neoplastic Transformation in Chronic Liver Disease. Part of a Coordinated Programme on in Vitro Assay Techniques. Final

摘要

To investigate the concentration of alpha fetoprotein (AFP) in different liver diseases and above all in liver cancer the immunoradiometric assay was utilized. The results of AFP studies were compared with regeneration index, blastic T lymphocytes transformation as well as other morphological and biochemical data. The results of the investigations indicated that: 38% of chronic benign hepatopathies displayed the values of serum AFP in normal ranges, 54% were in the range of 41 - 200ng/ml, and 8% showed 200 and more ng/ml. The most important conclusion from the work performed was that the elevation of serum AFP level in the evaluation of chronic hepatopathies, especially in cirrhoses, appears as an index of malignancy. (Atomindex citation 11:508532)