Different Effects of Dose Rate on Radiation-Induced Mutation Frequency in Various Germ-Cell Stages of the Mouse, and Their Implications for the Analysis of Tumorigenesis

摘要

The following factors affecting mutation induction by radiation in mice are discussed: dose rate, cell stage, and sex. It is suggested that for cancers of presumed mutational origin, the risk from chronic radiation exposure may be only one-third the risk from acute exposure. This is based only on responses of spermatogonia; other cell types behave quite differently. Specific and general applications are discussed. (ERA citation 04:045447)