Investigation of Radiopharmaceuticals from Cyclotron Produced Radionuclides and Development of Mathematical Models. Part of a Coordinated Programme on Production of Radiopharmaceuticals from Accelerator-Produced Isotopes. Final Re

摘要

Several radioisotopes for diagnostic uses in nuclear medicine studies are produced using the internal 15 MeV (30 MeV alphas) deuteron beam of the ''Ruder Boskovic'' Institute in Zagreb, Yugoslavia. Some of the most important radioisotopes produced during the last few years are: Gallium-67 (d, xn reaction on a Cu/Ni/Zn target) with yield of 7.6 MBq/uAh, exp 81 Rb-sup(81m)Kr generator ( alpha , 2n reaction on a Cu/Cu sub 2 Br sub 2 target) with a yield of 99 MBq/uAh, Iodine-123 ( alpha , 2n reaction on a Cu/Ag/Sb target) with a yield of 6.3 MBq/uAh, and Indium-111 ( alpha , 2n reaction on a Cu/Cu/Ag target) with a yield of 7.2 MBq/uAh. In addition, a simple mathematical lung model for regional ventilation measurements was developed and used for ventilation studies on normal subjects and subjects with various lung diseases. Based on these studies, a more sophisticated and quantitative lung ventilation model for radioactive tracer tidal breathing was further developed. In this new model, the periodicity of breathing is completely taken into account, and it makes possible to actually determine lung ventilation and volume parameters. The model is experimentally verified on healthy subjects, and the value of the effective specific ventilation obtained is in agreement with comparable parameters in the literature. sup(81m)Kr from a generator was used to perform these experimental studies. (Atomindex citation 14:792742)