Gastrointestinal Absorption of Plutonium in Mice, Rats, and Dogs: Application to Establishing Values of (f sub 1) for Soluble Plutonium.

摘要

The gastrointestinal (GI) absorption of plutonium was measured in mice, rats, and dogs under conditions relevant to setting drinking water standards. The fractional GI absorption of Pu (VI) in adult mice was 0.0002 (0.02%) in the fed mice and 0.002(0.2%) in fasted mice. The GI absorption of plutonium was independent of plutonium oxidation state, administration medium, and plutonium concentration; absorption was dependent upon animal species, state of animal fasting, state of Pu(IV) hydrolysis, and age of the animal. Fractional GI absorption values ranged from 0.00003(0.003%) for hydrolyzed Pu(IV) administered to fed adult mice to 0.007(0.7%) for Pu(VI) administered to fed neonatal rats.