Studies Involving the Reduction of SOD-Cu exp 2+ by CO sub 2- Radicals

摘要

Pulse radiolysis and other radiolytic techniques have proven very potent tools in the elucidation of the mechanism of O sub 2- dismutation by superoxide dismutases (SOD). Some recent work in this laboratory involved a systematic study of the reduction of SOD-Cu exp 2+ (bovine liver) by CO sub 2- radicals and the kinetics of the interaction between the resultant SOD-Cu exp + and peroxide, a process that is known to inactivate the enzyme and thought to generate a bound OH radical. 9 refs., 1 fig., 1 tab. (ERA citation 11:001124)