Derivation of a Specification for Fission-Produced Molybdenum-99 for the Preparation of AAEC (Autoclaved) Mk IIB /Sup 99/Mo//Sup 99M/Tc Generators

摘要

Technetium-99m eluates are shown to contain significantly lower levels of radionuclidic impurities than the parent /sup 99/Mo feed solution. It is well established that alumina absorption of /sup 99/Mo followed by saline elution of /sup 99m/Tc leads to a considerable overall decontamination effect. This decontamination factor (DF) is defined as the ratio of radionuclidic impurities in the /sup 99/Mo feed solution to radionuclidic impurities in the eluted /sup 99m/Tc. Impurity measurements were made on samples of fission product /sup 99m/Mo feed solutions and /sup 99m/Tc eluates from nominal 20 GBq and 150 GBq AAEC (autoclaved) Mk IIB generators. Minimum DFs were obtained which were then used to derive radionuclidic purity criteria for /sup 99/Mo to satisfy the requirements of the British Pharmacopoeia. (Atomindex citation 19:004574)