Analyses of Critical Target Cell Responses during Preclinical Phases of Evolving Chronic Radiation-Induced Myeloproliferative Disease-Exploitation of a Unique Canine Model

摘要

This document briefly summarizes and highlights ongoing studies on the cellular and molecular processes involved in the induction and progression of myeloid leukemia in dogs chronically exposed to low daily doses of wholebody gamma irradiation. Under such conditions, select groups of dogs exhibit extremely high frequencies of myeloproliferative disease (MPD) (i.e., about 50%) of which myeloid leukemia is most prominent. 2 figs. (ERA citation 14:023212)