High-resolution SPECT (single-photon emission-computed tomography) system based on a microchannel-plate imager.

摘要

We developed a high-resolution single-photon emission-computed tomography (SPECT) system for small-animal studies with (sup 125)I. The SPECT camera uses a Hamamatsu microchannel-plate imager PIAS (Photon-Counting Image Acquisition System), a 0.7 mm thick NaI(Tl) plate, and a lead-glass parallel-hole collimator. The 15-mm diameter field-of-view (FOV) of the PIAS tube was enlarged by an optical fiber face-plate taper to provide a 26 mm camera FOV. Camera absolute sensitivity is 2 (times) 10(sup -5) for (sup 125)I. The system provides an in-plane resolution of about 0.7 mm FWHM in the reconstructed image for a 15-mm radius of rotation. SPECT images from phantom studies and of organs in the rat and mouse provide examples of the resolving capacity of the system. 11 refs., 24 figs.