In vivo mutagenicity and clastogenicity of ionizing radiation in nuclear medicine. Annual technical progress report, (1991)

摘要

The overall goal of our research remains to investigate the mutagenic and clastogenic effects of exposure to low levels of ionizing radiation to human lymphocytes. Principally, we are studying hospital patients referred to a nuclear medicine department for diagnostic cardiac imaging and nuclear medicine technologies who administer radionuclides. Emphasis in the first year, as described in the first progress report, was on optimization of the hprt mutation assay, measurement of mutant frequencies in patients imaged with thallium-201, and measurement of mutant frequencies in controls. Emphasis in the second year has been on measurements of (1) chromosome aberrations in patients imaged with thallium-201, (2) mutant frequencies in patients imaged with technetium-99, (3) mutant frequencies in nuclear medicine technicians and physical therapists, (4) mutant frequencies in patients treated for Hodgkins disease with radiotherapy. The progress in these areas is described.