Measuring Intracranial Pressure and Correlation with Severity of Blast Traumatic Brain Injury.

摘要

A greater understanding of the mechanism(s) of TBI due from overpressure exposure is critical to develop effective protection and treatments. Fundamental, yet unresolved, questions concern the mode of blast energy transfer to the brain as well as the consequent damage or disruptive mechanisms at the cellular level. The ultimate goal of this research effort is to determine the intracranial pressure (ICP) responses to blast exposure. The objective of this research is to understand how pressure is transmitted through the brain and ascertain the relationship between levels of pressure transmission with severity of brain injury. Injury severity parameters were investigated during this year of the proposal. We used a shock tube model in which non-instrumented animals were be subjected to a single shock wave. Groups of animals were subjected to a different magnitude of overpressure. We present several neurological outcomes and neuropathologies that are unique to each pressure group. Overall, the large amount of data indicates molecular changes that occur depending on blast energy level.