Non-Invasive Detection of Axillary Nodes by Contrast Enhanced Magnetic Resonance Imaging

摘要

Previous studies in murine tumors have shown that the 3 drug combination of PALA + MMPR + 6AN (PMA) PALA (n-phosphonacetyl aspartate), MMPR (6-methylmercaptopurine riboside), 6AN (6- aminonicotinamide); referred to as PMA is an effective radiation (XRT) sensitizer. Using the MCF-7 human mammary tumor, we detected 6-phosphogluconate (6PG), an intermediate in the pentose phosphate pathway, and a reduction in nucleoside triphosphates after treatment with PMA in vivo. In vivo studies indicated that PMA induces a tumor response as evidenced by an increase in tumor growth delay from 10.2 +/-4.6 (control) to 29. 3 +/- 6.7 days. Neither PMA nor XRT alone induced tumor shrinkage. PMA yields 5 Gy induced tumor shrinkage and after 33 days the tumors had not attained their pretreatment volume. By day 51, the mice still had not doubled their tumor volume, indicating that PMA is an active regimen in human tumors, and an effective XRT sensitizer. We also investigated the efficacy of combining with paclitaxel with bryostatin.