Synthesis of New Tetraazacrown Ethers Capable of Forming Metal Ion Ligating Agents Containing Two Fluoroionophores or Chromoionophores

摘要

Four tetraazacrown ethers containing two unsubstituted ring nitrogen atoms were prepared via The crab-like cyclization reaction of two diamines with two bis-a-chloroamides followed by reduction of the resulting macrocyclic diamides. Thus, N,N'-dimethyltetraaza-15- crown-5 (12), N,N'-dimethyltetraaza- 16-crown-5 (13), N,N'-dimethyltetraa zathia-15-crown-5 (14), and N,N'- dimethyltetraazathia-l6-crown-5 (15) macrocyclic ligands were prepared. X-ray crystal structures were determined for the macrocyclic diamide intermediates leading to 13 and 14.