Liposome Delivery of a Potential Antidote for Mustard Exposure. An Overview and Integration of Data for Phase One Experiments by the Mustard Consortium, Regarding the Use of Antioxidants as a Counter Measure to Mustard

摘要

The mechanism of action of mustards has been unknown since its initial development. To date there has been no counter measure to this vesicant that could be utilized for systemic and skin exposure (both of which occur in combat conditions). The members of the Mustard Consortium hypothesized that oxidative reactions were a significant part of the inflammatory process that is responsible for the damage that occurs when an animal is exposed to mustards. If indeed oxidative reactions were a significant part of the mechanism of action, then the use of antioxidants would decrease damage to the exposed tissue. We also hypothesized that a new technology, the antioxidant liposome could be used as vehicle for the delivery of antioxidants. Antioxidants have been demonstrated to have a significant protective effect for both prior, and post exposure to mustards. The Consortium's strength is in the multidisciplinary approach to this complex problem. The group is able to incorporate information from outside sources and generate new information at faster rate, due to the ability to consult other members involved in different aspects of the same research project. Multiple models have been developed which also rapidly increase useful experimental data in the determination of a counter measure.