Genes in FRA16D and FRA7G Mutated in Prostate Cancer

摘要

The goal of this project was to characterize two common fragile site regions that had previously been shown to be frequently lost during the development of prostate cancer. FRA16D corresponds to the second most active common fragile site and is at chromosomal band 16q23.2. FRA7G is a much less active common fragile site at chromosomal band 7q32, but this region is frequently deleted in prostate tumors too. We have defined both fragile site regions and find that the region of instability surrounding FRA7G is approximately 300 Kb in size. The region of instability surrounding FRA16D is greater than 2 megabases. We have defined genes within these two regions and they include WWOX, caveolin-1, caveolin-2, and TESTIN. None of these genes were mutated in prostate tumors and none of those tested were found to act as genomic sensors. However, these genes are frequently not expressed in prostate tumors and may still play an important role in prostate tumor development.