Role of TGF-1B1-Mediated Down Regulation of NF-kB/Rel Activity During Growth Arrest of Breast Cancer Cells.

摘要

NF-kB/Rel is a family of transcription factors, which are expressed in all cells; however, in most non-B cells, they are sequestered in the cytoplasm in inactive complexes with specific inhibitory proteins, termed IKBs We have recently shown that NF-kB/Rel factors are aberrantly activated in breast cancer, and function to promote tumor cell survival Specifically, mammary tumors induced upon carcinogen treatment of Sprague-Dawley (S-D) rats, human breast tumor cell lines, and primary human breast tumor tissue samples were found to constitutively express high levels of nuclear NF-kB/Rel, whereas normal rat mammary glands and untransformed breast epithelial cells contained the expected low basal levels.