In Vivo Transcriptional Activation of Estrogen Receptor Target Genes: Differential Regulation in Mammary Gland Uterus and Bone

摘要

The purpose of this Career Development Award are to provide the salary support to foster the career development of the applicant and to study the Estrogen receptor (ER) target gene transcriptional activation in estrogen target organs. The scope of the research is to create an in vivo ER transactivation model to study the molecular mechanisms of estrogen, anti- estrogen, and growth factor action associated with ER target gene transcriptional activation in mammary gland, uterus, and bone. The major training accomplishment of this CDA is the promotions from non-tenure track Research Assistant Professor to tenure track Assistant Professor and then to Associate Professor, awards of ROl and other research grants, invitation to chair symposia at international meetings,-and invitation to various study sections. The applicant has established her own active research program in the area of breast cancer -research because of the support 4rom this CDA. The major research accomplishments include publications in major journals, presentations of data at international meetings, and several manuscripts in preparation. The major research findings include the successful establishment of an in vivo model of ER transactivation using adenovirus approach and the discovery of the segregation of steroid receptor coactivator-1 from Era in normal mammary epithelial cells.