Regulation of Apoptosis in Breast Cancer by NF-KappaB and IAB Axis

摘要

Defects in apoptosis contribute to the pathogenesis and progression of breast cancer. One of the modulators of apoptosis is NF-KappaB, a family of heterodimeric transcription factors containing a conserved REL homology domain. Apoptosis relevant targets of NF-KappaB include Bfl-1, bcl-X(sub L), FLIP, cIAP2, and others. We sought to identify novel regulators of NF-KappaB. We identified novel members of a family of PAAD/PYRIN domain-containing proteins, called PAs2 and NAC. These proteins modulate activity of the I-KappaB kinases (IKKs). Discovery of these novel NF-KappaB regulators provides new insights into mechanisms of apoptosis regulation and also may be of relevance to immune responses to breast cancers.