Association Between Offspring's hCG Genotype and Breast Cancer Risk in Mothers: A Novel Approach

摘要

We proposed to examine the novel hypothesis that the hCG genotype of a woman's offspring is associated with her breast cancer risk. Using the existing Metropolitan New York Registry (MNYR) resources, a case-control study was designed to examine the hypothesis whether first-born offspring's hCGBETA 5 genotype (i.e., placental hCGBETA 5 genotype during first full-term pregnancy) is associated with a woman's breast cancer risk. To date, the three tasks in the approved Statement of Work for year 1-3 have been accomplished. We have finished data analysis for the main results and we are in the process of manuscript preparation.