Transportable Life Support for Treatment of Acute Lung Failure Due to Smoke Inhalation and Burns

摘要

This proposal compares 3 currently marketed extracorporeal gas exchange (ECGE) devices as means to treat lung failure. Objective: assess the capacity of the Hemolung, Cardiohelp and PECLA to lower injurious ventilator settings during transport of combat casualties with lung failure. Hypothesis: when used in conjunction with mechanical ventilation respiratory therapy with the Hemolung, or Cardiohelp, or PECLA permits a 50% or more reduction in minute ventilation. Specific aims: (1) Compare therapeutic efficiency of each ECGE device to reduce minute ventilation in model of ARDS due to smoke inhalation and burns in swine; (2) compare gas exchange efficiency and benchmark the ECGE devices; (3) compare expression of local (lung) and systemic inflammatory mediators; (4) assess safety of ECGE devices. Study design: prospective randomized study in 40 animals (10 for each device/group and controls).