Prostate Cancer Mortality in Puerto Rican Men: The Effect of Body Habitus and Physical Activity

摘要

Prostate cancer kills more Puerto Rican men than cancers of the lung, trachea and bronchus. Physical activity has an inconsistent relationship with prostate cancer. It is not clear what the relationship between body habitus and physical activity is among non-Whites population. The underlying hypothesis of this epidemiological research is that excess body adiposity and sedentary lifestyles are independent risk factors for prostate cancer mortality in Puerto Rican men. The specific aims of this proposal are (1) to investigate the association between anthropometric measurements or changes in body weight and prostate cancer mortality, and (2) to study the relationship between physical activity and prostate cancer mortality. This study uses an observational longitudinal design with a random sample of 9,824 Puerto Rican men aged 35- 79 years at baseline (1964) who were part of the Puerto Rico Heart Health Program (PRHHP). Using a survival analysis approach and a total follow-up time of approximately 35 years we plan to examine the relationship of the above risk factors with prostate cancer mortality. There continues to be health disparities in prostate cancer incidence and mortality in minorities and our findings will improve our knowledge of the relationship between prostate cancer and other lifestyles.