Controlled Trial of Chemoprevention Using COX-2 Inhibitors in an Avian Model of Spontaneous Ovarian Carcinogenesis

摘要

While a strong rationale for chemoprevention of ovarian carcinoma exists, a mechanism for the comprehensive evaluation of novel compounds is severely impeded by the lack of a validated animal model of spontaneous ovarian carcinogenesis. At present, there is no verified, established model for this disease. In rodents, this type of cancer does not spontaneously develop. While studies investigating 'induced' carcinomas have been performed they are hindered by biologic differences in induced and spontaneous tumor formation. Identification of spontaneous ovarian carcinogenesis in the laying hen (Gallus Domesticus) may provide the answer to this dilemma. Multiple reports have demonstrated a 30-50% rate of spontaneously arising genital tract adenocarcinomas in hens of 3-6 years of age. Thus, the purpose of this study will be to utilize this animal model to evaluate the ability of a COX-2 inhibitor to reduce the incidence of spontaneous ovarian carcinogenesis in this animal model. More importantly, identification of promising agents in surrogate animal models that simulate a high risk population would significantly impact the strategy of cancer chemoprevention for ovarian carcinoma and lead to subsequent endeavors in this neglected area of study.