Bone Mineral Density, Sex Steroid Genes, Race and Prostate Cancer Risk

摘要

The goal of this project is to determine whether bone mineral density (assumed to be an integrated marker of sex steroid hormone exposure) is a risk factor for prostate cancer; and (2) to identify prostate cancer susceptibility alleles among genes in the sex steroid pathway. To address these aims, we undertook a case-control study of African American and Caucasian men in Pittsburgh, PA and Birmingham, AL. As of 6131106, 234 Caucasian and 56 African American (AA) cases and 237 Caucasian and 67 AA controls with PSA.