Modifiers of the Efficacy of Risk-Reducing Salpingo-Oophorectomy for the Prevention of Breast and Ovarian Cancer in Carriers of BRCA1 and BRCA2

摘要

The principle investigator was funded via a Physician-Scientist Training Award to participate in a comprehensive training plan to foster the transition to independent clinical breast cancer researcher. This plan included: 1) conduct of a prospective study examining modifiers of the efficacy of risk-reducing salpingo-oophorectomy for the prevention of breast and ovarian cancer in carriers of BRCA mutations; and 2) participation in a structured training program in research methodology biostatistics molecular biology and ethics. Progress from 5/1/2006 - 4/30/2007 includes: 1) Submission for publication the first prospective data examining the efficacy of risk-reducing salpingo-oophorectomy for the prevention of BRCA-associated breast and gynecologic cancer when BRCA2 mutation carriers are examined separately from BRCA1 mutation carriers.; 2) Continuation of training in genetic epidemiology laboratory methods outcomes analysis and conduct of clinical research through participation in the weekly laboratory meetings of Kenneth Offit MD MPH in addition to formal mentoring; and 3) Continued progress on a genetic epidemiologic computational and structural analysis of BRCA2 variants of uncertain significance funded by a peer-reviewed NIH award (1 R03 CA119265-01 to N.D.K.) to the principal investigator of this PTSA.