Development of Unique, Leading-Edge, Advanced Medical Research and Development Initiatives in the Western United States and Pacific Rim: Proton Beam Therapy Innovations.

摘要

Research and development of novel evaluative methods for proton beam radiotherapy is the primary research presented in this annual report. The long- term objective of this research was to develop a methodology for integrating as well as knowledge discovery of a DICOM-Radiation Therapy electronic patient record (ePR) system to manage patients with most types of Proton Beam Therapy (PT) treatment cases across multiple sites with DOD patients. As a first step, de-identified data samples from patients treated with PT at Loma Linda University Medical Center (LLUMC) was utilized for proof of concept for the research design, implementation, and evaluation. A prototype DICOM-based RT ePR Information System integrating all necessary RT related data and images was designed and presented at a Proton Therapy symposium. The objectives of the research focused on patient cases treated by PT at LLUMC because of the proximity and collaborative efforts between our research laboratory and LLUMC. The success of this proposal has tremendous impact to the US Military healthcare service, specifically in two parts: (1) Integration of clinical data obtained from PT clinical sites with DOD patients that can distributed globally to local peacetime stationary hospitals and clinics of cancer patients for tele- consulation and managed care. (2) Provide an infrastructure to perform large- scale horizontal and longitudinal outcome studies to improve clinical efficacy and efficiency to the patient.