Closed-Loop Resuscitation of Hemorrhagic Shock: Novel Solutions Infused to Hypotensive and Normotensive Endpoints

摘要

To define optimal fluid resuscitation regimens for use in combat casualty care. Specific goals are to determine the infusion regimens and fluids that are most efficient (least volume) and most effective (lowest mortality with best cardiovascular and metabolic function). We tested both FDA approved fluids and novel formulations. Our long-term goal is to develop efficient and efficacious resuscitation regimens for combat casualty care and to develop a microprocessor controlled closed-loop resuscitation system that will optimize the delivery of the solution(s) found best. Over the 3.75-year grant we completed 16 full studies, a total of 24 treatment groups with 218 individual experiments. Using our multi-bleed model conscious sheep hemorrhage model we studied 18 treatment groups in 124 experiments.