Simultaneous Monitoring of Vascular Oxygenation and Tissue Oxygen Tension of Breast Tumors Under Hyperbaric Oxygen Exposure

摘要

The overall goal of this research project is to apply the multiple monitoring techniques, i.e. Near infrared spectroscopy (NIRS), FOXY oxygen sensor and 19F MR EP imaging of Hexafluorobenzene (HFB), to prove the following hypotheses: combination of hyperbaric oxygen (HBO) intervention can significantly improve breast tumor oxygenation, and that tumor oxygenation remains elevated for a substantial period of time even after HBO exposure, which may be a novel approach to enhance radiosensitivity or chemotherapy. If our hypotheses are proven to be true, this study can lead to an optimal intervention plan to improve tumor oxygenation and to determine an optimal time interval after HBO decompression for radiotherapy. Such a novel approach will largely enhance the efficiency of non-surgical therapies for breast tumor treatment and provide a novel prognostic tool for clinical practice. This study will also provide a better understanding of tumor vasculature and tissue oxygen dynamics and spatial heterogeneity under HBO exposure.