Doxycycline Inhibits Vascular Leakage and Prevents the Development of Pulmonary Edema

摘要

The Vascular Leak Syndrome induced by blast injuries, burns, asphyxiation, and other injuries lead to progressive pulmonary edema, as well as tissue and limb swelling that contribute to morbidity and mortality of soldiers on the battlefield. The main goal of our research is the development and validation of novel therapies to prevent and reverse vascular leak syndromes. Our findings indicate that doxycycline, a commonly used antibiotic, inhibits vascular leak in a spectrum of pathologies.