Preparation of a Natural Product Extract Library for Investigation Against Disease States Specific to Defence Health: A Mini Long Range Research Project

摘要

This technical report outlines the research activities conducted during a mini Long Range Research project to establish a natural product extract library for drug discovery. The library was established with a view to it being screened against Defence health related targets. Discussed in this report are the research results generated from this project including establishing and chemically fingerprinting the extract library, in vitro results from screening a small selection of the library for antimalarial activity against parasites of Plasmodium falciparum, and the elucidation of the chemical structures of two compounds. The viability of conducting this type of research within the Human Protection and Performance Division at DSTO is also discussed.