Comprehensive 3D Model of Shock Wave-Brain Interactions in Blast- Induced Traumatic Brain Injuries

摘要

This project aims at the development of a realistic and accurate numerical model that can capture the essential physics of shock wave propagation and its interaction with the skull and brain tissue. This information would enable us to address and study the diverse mechanisms damaging the brain to better understand causes and effects during blast-induced traumatic brain injuries. At the present time, a fully 3D numerical model on fixed computational grids for nonlinear acoustic and elastic propagation has been developed and validated against published work and in-house experiments. A realistic modeling domain based on the segmentation and 3D reconstruction of sequential anatomical data obtained from the Visual Human Project is used as input to the computational kernel. Adaptive grid versions of the algorithms by means of wavelet and radial basis functions approaches as well as the inclusion of cavitation effects via effective medium theory and a graphical user interface to the simulation software are currently under development.